Cell Adhesion

Cell Adhesion It has been shown that the formation of adhesive complexes strengthens when mechanical force is applied to them. Furthermore, it has been experimentally demonstrated that force affects binding either by shortening bond lifetime – slip bond, or by prolonging bond lifetime – catch bond. We are developing the model ofstrain dependent binding of receptors to ligands. This model may mechanistically explain the above observations and elucidate important aspects of contraction-adhesion coupling and receptor-mediated regulation of cell functions in tissue, such as proliferation, adhesion, migration, differentiation, and cell death.