Multi-Scale Modeling

Multi-Scale Modeling Currently, only a few tools exist to investigate how, in an integrated framework, the mechanical environment influences biology (and vice versa) at the molecular, cellular and tissue scales. We are developing a computational platform that unites structure and function at molecular scale with higher-order organization and integrated physiological function. The resulting multi-scale model links biochemical kinetics and molecular organization to emergent mechanical properties and processes at hierarchical scales – spanning the molecular to tissue level. Using probabilistic and stochastic approaches to model protein binding kinetics, the model explicitly couples cell contractility and mechanics to adhesion: at an integrated molecular and cellular scale, and cellular and tissue scale.